Alcohol Metabolism and Toxicity: Role of Cytochrome P-450
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منابع مشابه
Alcohol metabolism and toxicity: role of cytochrome P-450.
A new isozyme of cytochrome P-450, designated from 3a on the basis of its relative electrophoretic mobility, has been purified to homogeneity from liver microsomes of rabbits treated chronically with ethanol. This cytochrome has the highest activity of the known rabbit P-450 isozymes in the oxidation of ethanol to acetaldehyde. In view of the reports of others that the hepatotoxicity of acetami...
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Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues of bioavailability and drug-drug interactions. The gene is known to be inducible by barbiturates, glucocorticoids, and rifampicin in humans and ...
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NADPH-cytochrome P-450 oxidoreductase (CPR) is essential for the catalytic activity of cytochrome P-450 (P-450). On a molar basis, the amount of P-450 exceeds that of CPR in human liver. In this study, we investigated whether drug-drug interactions can occur as a result of competition between P-450 isozymes for this ancillary protein. For this purpose, combinations of P-450 isozymes were coexpr...
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11. Loose, 1). S., Kan, P. H., Hirst, M. A., Marcus, R. A. and Feldman, L). A. (1983) J. Clin. Invest. 71, 1495I499 Santen, K. J., van den Bossche, H., Symoens, J., Hrugmans, J. and de Coster, R. (1 983) J. Clin. Endocrinol. Metab. 57,732-736 Schurmeyer, Th. and Nieschlag, E. (1984) Acta Endocrinol. 105,275-280 Sheets. J. J. and Mason, J. 1. (1984) Drug Metab. 1)ispos. 12,603-606 Mason, J. I., ...
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expression or are other molecular mechanisms operative? Unfortunately, we do not have precise answers to these questions at present owing to lack of information on the 5‘ upstream regulatory elements of genomic cytochrome P450 IVAl. It is interesting to draw attention to the mechanism proposed by Elcombe and his colleagues, whereby lipid biotransformation is again involved [ 151, similar to the...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1984
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/4.2part1.134